strixus:

currentsinbiology:

Epigenetic tie to neuropsychiatric disorders found

Dysfunction in dopamine signaling profoundly changes the activity level of about 2,000 genes in the brain’s prefrontal cortex and may be an underlying cause of certain complex neuropsychiatric disorders, such as schizophrenia, according to UC Irvine scientists.

This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.

The study, led by Emiliana Borrelli, a UCI professor of microbiology & molecular genetics, appears online in the journal Molecular Psychiatry.

K Brami-Cherrier, A Anzalone, M Ramos, I Forne, F Macciardi, A Imhof, E Borrelli. Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Molecular Psychiatry, 2014; DOI: 10.1038/mp.2014.67

Image via Resverlogix

Oh wow… this is amazing… 

This means that so many things that we’ve been looking for pure genetic causes for clearly aren’t, and yet at the same time they are environmentally inherited! 

(via teratocybernetics)

kierongillen:

Jim Steinman is amazing.

kierongillen:

Jim Steinman is amazing.


Bill Hicks

Bill Hicks

Bill Hicks

Bill Hicks

Bill Hicks

Bill Hicks

Bill Hicks

Bill Hicks

(via theremina)


People will stare. Make it worth their while → Alexander McQueen | Pre-Fall ‘10-‘11

People will stare. Make it worth their while → Alexander McQueen | Pre-Fall ‘10-‘11

People will stare. Make it worth their while → Alexander McQueen | Pre-Fall ‘10-‘11

People will stare. Make it worth their while → Alexander McQueen | Pre-Fall ‘10-‘11

People will stare. Make it worth their while → Alexander McQueen | Pre-Fall ‘10-‘11

People will stare. Make it worth their while → Alexander McQueen | Pre-Fall ‘10-‘11

(via distractedelf)

tvd-iron-fey-nerdy:

this is terrifying and beautiful at the same time
tvd-iron-fey-nerdy:

this is terrifying and beautiful at the same time

tvd-iron-fey-nerdy:

this is terrifying and beautiful at the same time

(via thegreenwolf)

catvincent:

thesylverlining:

themagicfarawayttree:

Medieval - Rabbits beating up man

about me

Anya Was Right

Represent!

catvincent:

As posted on my monthly column The Hype at Spiral Nature:

image

"The symbol at the top of the page is probably familiar to most modern (magical) practitioners. It’s the unicursal hexagram, the symbol Aleister Crowley designed to represent the religion he founded, Thelema, and as…

Running on The Default Network
by Boyce