Dysfunction in dopamine signaling profoundly changes the activity level of about 2,000 genes in the brain’s prefrontal cortex and may be an underlying cause of certain complex neuropsychiatric disorders, such as schizophrenia, according to UC Irvine scientists.
This epigenetic alteration of gene activity in brain cells that receive this neurotransmitter showed for the first time that dopamine deficiencies can affect a variety of behavioral and physiological functions regulated in the prefrontal cortex.
The study, led by Emiliana Borrelli, a UCI professor of microbiology & molecular genetics, appears online in the journal Molecular Psychiatry.
K Brami-Cherrier, A Anzalone, M Ramos, I Forne, F Macciardi, A Imhof, E Borrelli. Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Molecular Psychiatry, 2014; DOI: 10.1038/mp.2014.67
Image via Resverlogix
Oh wow… this is amazing…
This means that so many things that we’ve been looking for pure genetic causes for clearly aren’t, and yet at the same time they are environmentally inherited!
Shortly after Kathryn Tucker started RedRover, an app that showcases local events for kids, she pitched the idea to an angel investor at a New York tech event. But it didn’t go over well. When she finished her pitch, the investor said he didn’t invest in women.
When she asked why, he told her. “I don’t like the way women think,” he said. “They haven’t mastered linear thinking.” To prove his point, he explained that his wife could never prioritize her to-do lists properly. And then, as if he was trying to compliment her, he told Tucker she was different. “You’re more male,” he said.
Tucker didn’t need to hear any more. “I said, ‘Thanks very much,’ walked out, and never spoke to him again,” she recalled earlier this year, as part of a panel discussion on “fundraising while female” at the annual Internet Week conference in New York.”
As posted on my monthly column The Hype at Spiral Nature:
"The symbol at the top of the page is probably familiar to most modern (magical) practitioners. It’s the unicursal hexagram, the symbol Aleister Crowley designed to represent the religion he founded, Thelema, and as…